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CancerResveratrol: The Remarkable Anticancer Botanical

Resveratrol: The Remarkable Anticancer Botanical

Resveratrol is a polyphenolic compound produced by plants in response to environmental stress and can be found in at least 72 plant species, such as mulberries, peanuts, cranberries, blueberries, and grapes

Resveratrol is a natural stilbene containing two aromatic rings linked together by a methylene double bond to form 3,4′,5-trihydroxystilbene. It exists in both cis- and trans- isoforms. The trans form is more stable and potent than the cis form.  

Studies have reported that resveratrol exhibits many wide ranges of activities, including antioxidant,  anti-inflammatory, cardiovascular protective, anti-aging, and anticancer properties 

Recently, several studies have focused on the anticancer properties of resveratrol, which revealed a high ability to target multiple pathways involved in cancer initiation, promotion, and progression.  

Firstly, the antioxidant effects of resveratrol contribute significantly to the health benefits of this phytochemical, since it can act as a scavenger of a number of free radicals. In addition, resveratrol increases the expression of various antioxidant enzymes, such as SOD, catalase (CAT), glutathione reductase (GS-R), (GPx), and glutathione S-transferase (GST). Thus, resveratrol, through these two antioxidant effects, protects cells from oxidative damage  Conversely, as chemotherapeutics, resveratrol in combination with certain drugs can enhance apoptosis-inducing oxidative stress via induction of ROS .

A second possible anticancer mechanism of resveratrol is related to kinases, which play a critical role in cell growth and proliferation and are typically over-expressed in many tumours. Resveratrol specifically targets many kinases, including EGF, extracellular-signal-regulated kinases (ERK), and VEGF, thus decreasing their expression and resulting in antigrowth signalling activity. 

A third suggested mechanism for the anticancer activity of resveratrol is related to its anti-inflammatory activity, since several types of cancer are, to some extent, promoted by a certain degree of systemic, low-grade chronic inflammation. Ren et al. have reported that resveratrol suppresses the inflammatory biomarker tumour necrosis factor α (TNF-α-)-induced signalling in a dose-dependent manner, both via nuclear factor kappa-B (NFκB) activation and transcriptional activity of p65. Furthermore, in colon cancer, resveratrol can help induce cell cycle arrest at the G1 phase. That was achieved by lowering cyclin E1 and cyclin D1 and increasing p53 in a dose-dependent manner. In addition, resveratrol treatment resulted in increasing p27 and p21 gene expression levels, as well as lowering cyclin B gene expression. In ovarian cancer cells, resveratrol has been shown to help inhibit proliferation and help induce apoptosis via inhibiting glycolysis and targeting the AMPK/mTOR signaling pathway. In pancreatic cancer cells, resveratrol help suppress the metastatic potential in vitro by modulating EMT-related factors via the PI3K/Akt/NF-κB signaling pathway.

If this was not encouraging enough, Lee et al. have demonstrated that resveratrol increases the expression of activating receptors on natural killer (NK) cells, an effect which could facilitate NK-cell-mediated killing of cancer cells

Finally, resveratrol shows a synergistic inhibitory effect on the proliferation of various cancer cells and improves the effect of many chemotherapeutic agents, such as temozolomide, cisplatin, doxorubicin, 5-fluorouracil, gemcitabine, docetaxel, and paclitaxel 

Resveratrol appears to be well tolerated, with no significant harm recorded against normal cells. Beware that not all products containing resveratrol are equally effective. To know more, ask us!

References:

 Hogg S.J., Chitcholtan K., Hassan W., Sykes P.H., Garrill A.J. Resveratrol, acetyl-resveratrol, and polydatin exhibit antigrowth activity against 3D cell aggregates of the SKOV-3 and OVCAR-8 ovarian cancer cell lines. Obstet. Gynecol. Int. 2015;2015:279591. doi: 10.1155/2015/279591. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Varoni E.M., Lo Faro A.F., Sharifi-Rad J., Iriti M. Anticancer molecular mechanisms of resveratrol. Front. Nutr. 2016;3:8. doi: 10.3389/fnut.2016.00008. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Ren Z., Wang L., Cui J., Huoc Z., Xue J., Cui H., Mao Q., Yang R. Resveratrol inhibits NF-κB signaling through suppression of p65 and IB kinase activities. Die Pharm.-Int. J. Pharm. Sci. 2013;68:689–694. [PubMed] [Google Scholar]
Li D., Wang G., Jin G., Yao K., Zhao Z., Bie L., Guo Y., Li N., Deng W., Chen X. Resveratrol suppresses colon cancer growth by targeting the AKT/STAT3 signaling pathway. Int. J. Mol. Med. 2019;43:630–640. doi: 10.3892/ijmm.2018.3969. [PubMed] [CrossRef] [Google Scholar]
Heo J.R., Kim S.M., Hwang K.A., Kang J.H., Choi K.C. Resveratrol induced reactive oxygen species and endoplasmic reticulum stress-mediated apoptosis, and cell cycle arrest in the A375SM malignant melanoma cell line. Int. J. Mol. Med. 2018;42:1427–1435. doi: 10.3892/ijmm.2018.3732. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Li L., Qiu R.L., Lin Y., Cai Y., Bian Y., Fan Y., Gao X.J. Resveratrol suppresses human cervical carcinoma cell proliferation and elevates apoptosis via the mitochondrial and p53 signaling pathways. Oncol. Lett. 2018;15:9845–9851. doi: 10.3892/ol.2018.8571. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Liu Y., Tong L., Luo Y., Li X., Chen G., Wang Y. Resveratrol inhibits the proliferation and induces the apoptosis in ovarian cancer cells via inhibiting glycolysis and targeting AMPK/mTOR signaling pathway. J. Cell. Biochem. 2018;119:6162–6172. doi: 10.1002/jcb.26822. [PubMed] [CrossRef] [Google Scholar]
Li W., Ma J., Ma Q., Li B., Han L., Liu J., Xu Q., Duan W., Yu S., Wang F. Resveratrol inhibits the epithelial-mesenchymal transition of pancreatic cancer cells via suppression of the PI-3K/Akt/NF-κB pathway. Curr. Med. Chem. 2013;20:4185–4194. doi: 10.2174/09298673113209990251. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
 Li J., Chong T., Wang Z., Chen H., Li H., Cao J., Zhang P., Li H. A novel anti-cancer effect of resveratrol: Reversal of epithelial-mesenchymal transition in prostate cancer cells. Mol. Med. Rep. 2014;10:1717–1724. doi: 10.3892/mmr.2014.2417. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

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Cancer Fatigue

Cancer-related is one of the most common side effects of cancer and its treatments. Like fatigue, cancer fatigue is whole-body exhaustion that you feel no matter how much sleep or rest you get. Cancer fatigue takes exhaustion a step further: You feel physically, emotionally and mentally exhausted most of the time. Cancer fatigue may last a few weeks (acute) or for months or years (chronic).

To improve energy effectively, we provide modalities ranging from mindfulness-based cognitive therapy therapies, to herbal medicine and targeted nutritional interventions.

Pain Management

Providing quality care and services to our patients is our utmost commitment. Our approach prioritises a holistic and integrative method to health and wellness, ensuring that each patient receives personalised and effective treatment.

Our acupuncture services, including traditional acupuncture, medical acupuncture, and laser acupuncture, are designed to stimulate the body's natural healing processes, reduce pain, and improve overall health. In addition to acupuncture, we provide specialised physiotherapy services aimed at restoring movement, improving function, and alleviating pain Our commitment to quality care is reflected in our dedication to continuously improving our services and staying abreast of the latest advancements in medical and complementary treatments.

We are devoted to helping our patients achieve the best possible health outcomes through compassionate, comprehensive, and patient-centred care.

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Recovery

Helping you to thrive into enduring wellness after the conclusion of cancer treatments is our goal. At Vitawell Wellness we understand that an optimised immune system comes from a foundation of basics. Quality of sleep, exercise, enjoying nature, and practising meditation are incredibly important elements to aid in your recovery.

Our holistic approach focuses on rebuilding all the components that form your unique profile, from weight and movement to mind-body connection; from good energy to healthy weight; from sleep to finding happiness in small things.  Recovery also depends upon restoring imbalances in your immune system, nervous system, neurotransmitters, gut health, adrenal and hormonal systems. At Vitawell Wellness we will provide you with the essential tools and the appropriate program to achieve and to maintain optimal health and enduring wellness.

Stress Management

The state of mind impacts health through the mind-body connection. We believe that  that body and mind are one, that the mind feeds the body just as the body feeds the mind. Since emotions, feelings, thoughts, beliefs, actions, and behaviour impact and literally shape wellbeing, we provide the necessary tools to  strengthen your mental and emotional inner life.

We strive to help you cultivate and maintain hope, calm, optimism, and inner-peace. We want to know how you feel; we listen and support you in regaining power with positive actions, step-by-step into wellness. 

Clinical Detox

After the conclusion of cancer treatments, we strongly recommend that you follow our clinical detoxification program. At Vitawell Wellness we are aware tht some common side-effects from chemotherapy or radiation therapy treatments can have lasting effects such as brain fog, loss of energy and gastro-intestinal dysfunction.

We strongly believe in the power of detoxification as a method of steadily reducing toxins` accumulation and regaining strength, balance, and imporve wellness. Our personalised program is sensible, gentle but effective, and includes stress reduction technique and lifestyle changes.

Personalised Diet

The relationship between cancer, diet, energy, muscle mass and optimal weight is extremely important. At Vitawell Wellness we focus on addressing your current nutritional status and develop the right diet for you.  "One size does not fit all" principle applies to your diet. Each person is unique and therefore variability exists between nutrient-sense diets.

We provide personalised and appropriate dietary plans before, during and after cancer treatments. We provide 7 day menu plan, shopping lists and recipes that reflect food preferences and sensitivities. The menu plans are easy to follow. Each food is selected for its specific content of nutrients. Healthy foods positively support your whole person wellness.

For some, reaching wellness means improving body weight, muscle mass, digestion, assimilation and gut microbiome. 

For some, reaching wellness means reducing body weight, improving muscle mass, digestion, bowel function and gut microbiome. Obesity and overweight have been shown to increase cancer risk.

Preventive Care

The Functional Medicine model is an individualised, patient-centred, science-based approach that empowers patients and practitioners to work together and to address the underlying causes of disease and promote optimal wellness.

Functional Medicine is gaining attention as a new approach to care in large institutions and Universities around the world. This is leading to new approaches to investigate ways to research outcomes of Functional Medicine designed to discover and remedy root causes of problems instead of suppressing symptoms. Random controlled trials are beginning to be conducted, and a new body of literature is beginning to emerge in this realm as a result.

Nutritional Medicine

Nutrition medicine is a personalised medicine that deals with primary prevention and addresses underlying causes instead of treating symptoms for serious chronic diseases. By shifting the traditional disease-centred focus of medical practice to a more patient-centred approach, nutritional medicine individualises the patient's nutritional needs based on genetic, environmental, and personal considerations.

Nutritional medicine focuses on shifting dietary habits to optimise personal health stimulating the powerful inert healing mechanism within each person by providing nutrient protocols and specialised diets for each individual need.

Herbal Medicine

Herbalism today is based on remedies and techniques tried and tested through generations of use, but increasingly re-evaluated in the light of modern medical refinements. A key feature of herbalism is that remedies are used to support and modify disturbed body functions.

Herbal medicine is the oldest and still the most widely used system of medicine in the world today. It is medicine made exclusively from plants. It is used in all societies and is common to all cultures.

Herbal medicine is increasingly being validated by scientific investigation which seeks to understand the active chemistry of the plant. Many modern pharmaceuticals have been modelled on, or derived from, phytochemicals found in plants. Increasing research on herbal medicine demonstrates that liquid botanicals play a critical role during, before and after a diagnosis of cancer.

Individualised Plans

Cancer requires negotiation and navigation. Decisions must be made. Directions must be pursued. The decisions and directions often occur in the middle of stress, fear, trauma, and many other challenging emotions. The skills with which people negotiate and navigate their cancer journey are better supported by combining conventional treatments with evidence-based natural medicine.

At Vitawell Wellness, we design individual programs to support you regardless of your diagnosis and the stage of your cancer. We collect all critical information about your state of health and help you in your decision-making process with the wisdom and the experience that comes from years of clinical practice. We work in alignment with what you think, feel, say, and do. In this way, we honour your self-awareness, your knowledge and views and integrate them in safe practices.