Resveratrol is a polyphenolic compound produced by plants in response to environmental stress and can be found in at least 72 plant species, such as mulberries, peanuts, cranberries, blueberries, and grapes
Resveratrol is a natural stilbene containing two aromatic rings linked together by a methylene double bond to form 3,4′,5-trihydroxystilbene. It exists in both cis- and trans- isoforms. The trans form is more stable and potent than the cis form.
Studies have reported that resveratrol exhibits many wide ranges of activities, including antioxidant, anti-inflammatory, cardiovascular protective, anti-aging, and anticancer properties
Recently, several studies have focused on the anticancer properties of resveratrol, which revealed a high ability to target multiple pathways involved in cancer initiation, promotion, and progression.
Firstly, the antioxidant effects of resveratrol contribute significantly to the health benefits of this phytochemical, since it can act as a scavenger of a number of free radicals. In addition, resveratrol increases the expression of various antioxidant enzymes, such as SOD, catalase (CAT), glutathione reductase (GS-R), (GPx), and glutathione S-transferase (GST). Thus, resveratrol, through these two antioxidant effects, protects cells from oxidative damage Conversely, as chemotherapeutics, resveratrol in combination with certain drugs can enhance apoptosis-inducing oxidative stress via induction of ROS .
A second possible anticancer mechanism of resveratrol is related to kinases, which play a critical role in cell growth and proliferation and are typically over-expressed in many tumours. Resveratrol specifically targets many kinases, including EGF, extracellular-signal-regulated kinases (ERK), and VEGF, thus decreasing their expression and resulting in antigrowth signalling activity.
A third suggested mechanism for the anticancer activity of resveratrol is related to its anti-inflammatory activity, since several types of cancer are, to some extent, promoted by a certain degree of systemic, low-grade chronic inflammation. Ren et al. have reported that resveratrol suppresses the inflammatory biomarker tumour necrosis factor α (TNF-α-)-induced signalling in a dose-dependent manner, both via nuclear factor kappa-B (NFκB) activation and transcriptional activity of p65. Furthermore, in colon cancer, resveratrol can help induce cell cycle arrest at the G1 phase. That was achieved by lowering cyclin E1 and cyclin D1 and increasing p53 in a dose-dependent manner. In addition, resveratrol treatment resulted in increasing p27 and p21 gene expression levels, as well as lowering cyclin B gene expression. In ovarian cancer cells, resveratrol has been shown to help inhibit proliferation and help induce apoptosis via inhibiting glycolysis and targeting the AMPK/mTOR signaling pathway. In pancreatic cancer cells, resveratrol help suppress the metastatic potential in vitro by modulating EMT-related factors via the PI3K/Akt/NF-κB signaling pathway.
If this was not encouraging enough, Lee et al. have demonstrated that resveratrol increases the expression of activating receptors on natural killer (NK) cells, an effect which could facilitate NK-cell-mediated killing of cancer cells
Finally, resveratrol shows a synergistic inhibitory effect on the proliferation of various cancer cells and improves the effect of many chemotherapeutic agents, such as temozolomide, cisplatin, doxorubicin, 5-fluorouracil, gemcitabine, docetaxel, and paclitaxel
Resveratrol appears to be well tolerated, with no significant harm recorded against normal cells. Beware that not all products containing resveratrol are equally effective. To know more, ask us!
References:
Hogg S.J., Chitcholtan K., Hassan W., Sykes P.H., Garrill A.J. Resveratrol, acetyl-resveratrol, and polydatin exhibit antigrowth activity against 3D cell aggregates of the SKOV-3 and OVCAR-8 ovarian cancer cell lines. Obstet. Gynecol. Int. 2015;2015:279591. doi: 10.1155/2015/279591. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Varoni E.M., Lo Faro A.F., Sharifi-Rad J., Iriti M. Anticancer molecular mechanisms of resveratrol. Front. Nutr. 2016;3:8. doi: 10.3389/fnut.2016.00008. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Ren Z., Wang L., Cui J., Huoc Z., Xue J., Cui H., Mao Q., Yang R. Resveratrol inhibits NF-κB signaling through suppression of p65 and IB kinase activities. Die Pharm.-Int. J. Pharm. Sci. 2013;68:689–694. [PubMed] [Google Scholar]
Li D., Wang G., Jin G., Yao K., Zhao Z., Bie L., Guo Y., Li N., Deng W., Chen X. Resveratrol suppresses colon cancer growth by targeting the AKT/STAT3 signaling pathway. Int. J. Mol. Med. 2019;43:630–640. doi: 10.3892/ijmm.2018.3969. [PubMed] [CrossRef] [Google Scholar]
Heo J.R., Kim S.M., Hwang K.A., Kang J.H., Choi K.C. Resveratrol induced reactive oxygen species and endoplasmic reticulum stress-mediated apoptosis, and cell cycle arrest in the A375SM malignant melanoma cell line. Int. J. Mol. Med. 2018;42:1427–1435. doi: 10.3892/ijmm.2018.3732. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Li L., Qiu R.L., Lin Y., Cai Y., Bian Y., Fan Y., Gao X.J. Resveratrol suppresses human cervical carcinoma cell proliferation and elevates apoptosis via the mitochondrial and p53 signaling pathways. Oncol. Lett. 2018;15:9845–9851. doi: 10.3892/ol.2018.8571. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Liu Y., Tong L., Luo Y., Li X., Chen G., Wang Y. Resveratrol inhibits the proliferation and induces the apoptosis in ovarian cancer cells via inhibiting glycolysis and targeting AMPK/mTOR signaling pathway. J. Cell. Biochem. 2018;119:6162–6172. doi: 10.1002/jcb.26822. [PubMed] [CrossRef] [Google Scholar]
Li W., Ma J., Ma Q., Li B., Han L., Liu J., Xu Q., Duan W., Yu S., Wang F. Resveratrol inhibits the epithelial-mesenchymal transition of pancreatic cancer cells via suppression of the PI-3K/Akt/NF-κB pathway. Curr. Med. Chem. 2013;20:4185–4194. doi: 10.2174/09298673113209990251. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Li J., Chong T., Wang Z., Chen H., Li H., Cao J., Zhang P., Li H. A novel anti-cancer effect of resveratrol: Reversal of epithelial-mesenchymal transition in prostate cancer cells. Mol. Med. Rep. 2014;10:1717–1724. doi: 10.3892/mmr.2014.2417. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
